NIME Next Batch PGI Quest in Delhi from 10 August to 20 August
B. Is not a somatostatin analogue
C. Used in secretory diarrhea
D. Is a growth hormone agonist
Ans. C.
• Octreotide is a synthetic octapeptide with actiàns similar to somatostatin.
• Routes of administration:
- Intravenous (v. short duration of action)
- Subcutaneous
- Intramuscular (depot preparation)
• It is 40 times more potent than somatostatin in suppressing GH secretion.
• It is being preferred over somatostain for acromegaly and secretory diarrheas associated with carcinoid, AIDS, cancer chemotherapy or diabetes
Uses
Based on properties of inhibiting secretion of various hormones (GH, TSH, PL, insulin, glucagon), all Gl secretions
(including gastrin & HCI) and constriction of splanchnic, hepatic and renal blood vessels.
• Carcinoid and VIPoma induced secretory diarrhea and systemic symptoms such as flushing and wheezing.
• Diarrhea due to vagotomy and dumping syndrome, short bowel syndrome or AIDS.
• Cl bleeding
• Pancreatic fistula, insulinoma, glucagonoma, pancreatic ascites
• Oncogenic osteomalacia
• Acromegaly
Adverse effects: Abdominal pain, nausea, steatorrhoea, diarrhea, gall stones.
True about Octreotide:
A. Is active orallyB. Is not a somatostatin analogue
C. Used in secretory diarrhea
D. Is a growth hormone agonist
Ans. C.
• Octreotide is a synthetic octapeptide with actiàns similar to somatostatin.
• Routes of administration:
- Intravenous (v. short duration of action)
- Subcutaneous
- Intramuscular (depot preparation)
• It is 40 times more potent than somatostatin in suppressing GH secretion.
• It is being preferred over somatostain for acromegaly and secretory diarrheas associated with carcinoid, AIDS, cancer chemotherapy or diabetes
Uses
Based on properties of inhibiting secretion of various hormones (GH, TSH, PL, insulin, glucagon), all Gl secretions
(including gastrin & HCI) and constriction of splanchnic, hepatic and renal blood vessels.
• Carcinoid and VIPoma induced secretory diarrhea and systemic symptoms such as flushing and wheezing.
• Diarrhea due to vagotomy and dumping syndrome, short bowel syndrome or AIDS.
• Cl bleeding
• Pancreatic fistula, insulinoma, glucagonoma, pancreatic ascites
• Oncogenic osteomalacia
• Acromegaly
Adverse effects: Abdominal pain, nausea, steatorrhoea, diarrhea, gall stones.
