NIME Next Batch PGI Quest in Delhi from 10 August to 20 August
B. Increasing activity of acetyl carboxylase
C. Decrease of cAMP in cell
D. Causes glucose to move in the cell
Insulin causes increased lipogenesis by all of following EXCEPT
A. Inhibition of pyruvate dehydrogenaseB. Increasing activity of acetyl carboxylase
C. Decrease of cAMP in cell
D. Causes glucose to move in the cell
Ans. A. (Inhibition of pyruvate dehydrogenase)
Explanation
Insulin stimulates lipogenesis by the following:
Insulin stimulates lipogenesis by the following:
•
Increasing acetyl CoA carboxylase activity.
•
Increasing transport of glucose into cell (adipose tissue).
•
Converts inactive form of pyruvate dehydrogenase to active form in adipose
tissue.
•
Insulin, by its ability to depress the level of intracellular cyclic AMP and
inhibit lipogenesis in adipose tissue, decreases the concentration of plasma
FFA and therefore long-chain acetyl CoA, which is the inhibitor of lipogenesis.
