NIME Next Batch PGI Quest in Delhi from 10 August to 20 August
B. T (8 21)
C. Normal karyotype
D. Monosom
Poor prognostic factor in AML
A. mv 16B. T (8 21)
C. Normal karyotype
D. Monosom
Ans. D. (Monosomy 7)
Explanation
AML arising de novo in patients with no risk factors are often associated with balanced chromosomal translocations, particularly t (8;2 1), mv (16), and t (15; 17). In contrast, AMLs following myelodysplastic syndromes or exposure to DNA- damaging agents (such as chemotherapy or radiation therapy) are commonly associated with deletions or monosomie involving chromosomes 5 and 7 and usually lack chromosomal translocations. AMLs associated with t (8;2 1) or mv (16) have a relatively good prognosis with conventional chemotherapy. In contrast, the prognosis is dismal for patients with AML with prior myelodysplastic syndrome or following genotoxic therapy, possibly because of damage to normal hematopoietic stem cells.
AML arising de novo in patients with no risk factors are often associated with balanced chromosomal translocations, particularly t (8;2 1), mv (16), and t (15; 17). In contrast, AMLs following myelodysplastic syndromes or exposure to DNA- damaging agents (such as chemotherapy or radiation therapy) are commonly associated with deletions or monosomie involving chromosomes 5 and 7 and usually lack chromosomal translocations. AMLs associated with t (8;2 1) or mv (16) have a relatively good prognosis with conventional chemotherapy. In contrast, the prognosis is dismal for patients with AML with prior myelodysplastic syndrome or following genotoxic therapy, possibly because of damage to normal hematopoietic stem cells.
