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B. Associated with paraneoplastic syndrome
C. Don’t cause SVC syndrome
D. Chemosensitive
E. Commonly present with metastasis to brain.
Small cell carcinoma features are:
A. Commonest malignancy of lungB. Associated with paraneoplastic syndrome
C. Don’t cause SVC syndrome
D. Chemosensitive
E. Commonly present with metastasis to brain.
Ans. B.
Associated with paraneoplastic syndrome
; (D) Chemosensitive
(E) Commonly present with metastasis to brain
• Adenocarcinoma of lung is most common carcinoma of
lung. Other varieties as decreasing
frequency in incidence are: Squamous cell Ca, small cell Ca, large cell Ca and
bronchoalveola Ca.
• Small cell Ca is alw paraneoplastic syndrome e.g.
ACTH and ANP or ADH produced by small cell Ca.
• Both small cell Ca and
squamous cell Ca cause superior vena cava syndrome.
• Small cell Ca is sensitive to chemotherapy. Response
to cisplatin and etoposide are excellent. 80- 100% response in limited stage
disease
• Approx 1/3rd of patients with Lung cancer presents
with symptoms due to metastatic spread outside the thorax. Skeletal metastasis
which are most commonly seen in small cell and large cell tumous.
• Small cell cancer grows
rapidly and widely highly malignant tumour and over 2/3rd of
patients presents with evidence of extensive disease with metastasis. The
important clinical sites includes Liver, CNS & Bone. Other less frequent sites
are abdominal lymphnode adrenals& other abdominal organs.
