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Which of the following chemotherapy agent can cause syndrome of Inappropriate ADH secretion (SIADH)?
A. Vincristine
B. Vinblastine
C. Dacarbazine
D. Cyclophosphamide
Carbamazepine
Phenothiazines
TCAs
MACIs
SSRIs
Which of the following chemotherapy agent can cause syndrome of Inappropriate ADH secretion (SIADH)?
A. Vincristine
B. Vinblastine
C. Dacarbazine
D. Cyclophosphamide
Ans. A. Vincristine
Causes of SIADH:
Neoplasms:
Carcinoma - lung, duodenum, pancreas, ovary, Mesothelioma, Branchial adenoma, Carcinoid, Ewing sarcoma
Head trauma
Infections- Pneumonia
Abscess (lung or brain)
Cavitation (aspergillosis)
TB (lung or brain)
Meningtis (Bacterial or viral)
Causes of SIADH:
Neoplasms:
Carcinoma - lung, duodenum, pancreas, ovary, Mesothelioma, Branchial adenoma, Carcinoid, Ewing sarcoma
Head trauma
Infections- Pneumonia
Abscess (lung or brain)
Cavitation (aspergillosis)
TB (lung or brain)
Meningtis (Bacterial or viral)
Encephalitis
AIDS
Vascular:
Cerebrovascular occlusions, hemorrhage, Cavernous sinus thrombosis
Neurologic:
CBS, MS, ALS, Delirium tremens, Hydrocephalus, Psychosis, Peripheral neuropathy.
Metabolic:
Acute intermittent prophyria
Pulmonary:
Asthma
Pneumothorax
Positive pressure ventilation
Drugs:.
Vasopressin or Desmopressin
Chlorpropamide
Vincristine,
Cyclophosphamide AIDS
Vascular:
Cerebrovascular occlusions, hemorrhage, Cavernous sinus thrombosis
Neurologic:
CBS, MS, ALS, Delirium tremens, Hydrocephalus, Psychosis, Peripheral neuropathy.
Metabolic:
Acute intermittent prophyria
Pulmonary:
Asthma
Pneumothorax
Positive pressure ventilation
Drugs:.
Vasopressin or Desmopressin
Chlorpropamide
Carbamazepine
Phenothiazines
TCAs
MACIs
SSRIs